Correlation between major histocompatibility complex class I-related chain A gene alleles and graft rejection in small intestine, liver and kidney transplantation.
- Author:
Liang HE
1
;
Gang JI
;
Guang-long DONG
;
Wei-zhong WANG
;
Kai-shan TAO
;
Geng ZHANG
;
Yu-hai ZHANG
;
Bo-quan JIN
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Graft Rejection; genetics; immunology; Histocompatibility Antigens Class I; genetics; Humans; Intestine, Small; transplantation; Kidney Transplantation; immunology; Liver Transplantation; immunology; Living Donors; Organ Transplantation
- From: Chinese Journal of Surgery 2009;47(14):1070-1074
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the correlation between major histocompatibility complex (MHC) class I chain-related gene A (MICA) gene alleles matching rates and graft rejection in small intestine, liver and kidney transplantation.
METHODSGenome DNA were extracted from blood samples or pathological sections collected from donors and recipients of living-related transplantation, included 4 cases of small bowel transplantation, 5 cases of liver transplantation and 6 cases of kidney transplantation. The correlation between MICA alleles matching rates and acute graft rejection was analyzed following 13 MICA alleles determination by polymerase chain reaction based on sequence-specific primers (PCR-SSP).
RESULTSHLA zygosity of all donors and recipients was confirmed to be half-matching. The recipients displaying higher matching rates of MICA alleles with donors showed lighter clinical and pathological rejection and longer survival time. On the contrary, recipients with lower matching rates of MICA alleles with donors showed severer clinical and pathological rejection and shorter survival time relatively.
CONCLUSIONMatching rates of MICA alleles has negative relevance to acute rejection, and positive relevance to survival time of recipients in small bowel, liver, and kidney transplantation.
