Successful Graft Recovery from Thrombotic Acute Kidney Injury in a Kidney Transplant Patient with Antiphospholipid Syndrome.
10.4285/jkstn.2013.27.3.128
- Author:
Younjeong CHOI
1
;
Hyewon LEE
;
Yujung YUN
;
Youngki LEE
;
Eudong HWANG
;
Hyeonjoo JEONG
;
Beom Seok KIM
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. docbsk@yuhs.ac
- Publication Type:Case Report
- Keywords:
Antiphospholipid syndrome nephropathy;
Antiphospholipid syndrome;
Antiphospholipid antibodies;
Lupus coagulation inhibitor;
Kidney transplantation
- MeSH:
Acute Kidney Injury;
Antibodies, Antiphospholipid;
Antiphospholipid Syndrome;
Humans;
Kidney;
Kidney Transplantation;
Lupus Coagulation Inhibitor;
Risk Factors;
Transplantation, Homologous;
Transplants
- From:The Journal of the Korean Society for Transplantation
2013;27(3):128-131
- CountryRepublic of Korea
- Language:English
-
Abstract:
Antiphospholipid syndrome nephropathy (APSN) is well documented in the literature as the renal involvement of the antiphospholipid syndrome (APS). A review of literature also shows that among antiphospholipid antibodies, lupus anticoagulant (LA) positivity is recognized as the strongest risk factor for APSN. In addition, APSN is also known to be associated with a poor functional outcome in the first posttransplant year. Therefore, it is a general belief that renal transplantation may be life threatening in APS patients. Furthermore, the presence of LA at the time of transplantation is particularly associated with a high rate of allograft APSN and the consequent poor transplantation outcomes. Here, we report the case that thrombotic acute kidney injury due to APSN after kidney transplantation can be successfully treated if anticoagulation therapy is timely applied with a prompt diagnosis.
