Association between positive autoantibodies against AT1-receptor and cardiac remodeling in patients with hypertension.
- Author:
Yan QIU
1
;
Feng ZHU
;
Yu-hua LIAO
;
Zheng-zai LI
;
Min WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Autoantibodies; blood; Female; Heart Ventricles; physiopathology; Humans; Hypertension; blood; immunology; physiopathology; Hypertrophy, Left Ventricular; Male; Middle Aged; Receptor, Angiotensin, Type 1; immunology; Ventricular Remodeling
- From: Chinese Journal of Cardiology 2007;35(12):1141-1144
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the association between positive autoantibodies against AT(1)-receptor and cardiac remodeling in primary hypertensive patients.
METHODSEchocardiography was performed and serum autoantibodies against AT(1)-receptor were detected by enzyme linked immunosorbent assay (ELISA) in 592 patients with primary hypertension. The differences on blood pressure level, course of hypertension, vasoactive substance and echocardiography parameters between the positive group and negative group were compared. Factors related to left ventricular enlargement were analyzed by multiple logistic regressions.
RESULTSThe positive percentage of autoantibodies against AT(1)-receptor was 38.0% (225/592). End-diastolic right atrial and left ventricular diameters in positive group were significantly larger than that in negative group (P = 0.049 and P = 0.044, respectively). Regression analysis demonstrated that positive autoantibodies against AT(1)-receptor, male gender, diastolic blood pressure and course of hypertension were related to left ventricular enlargement (all P < 0.05).
CONCLUSIONThe autoantibodies against AT(1)-receptor is associated with left ventricular and right atrial enlargement in hypertensive patients.
