Pulmonary function testing in Chinese patients with pulmonary arterial hypertension
10.3321/j.issn:0253-3758.2008.01.002
- VernacularTitle:肺动脉高压患者肺功能特点分析
- Author:
Zhi-Cheng JING
1
;
Xi-Qi XU
;
Yan WU
;
Wei ZHANG
;
Hui-Ying ZHAO
;
Xiong LUO
;
Li ZHAI
;
Xin JIANG
;
Hao LU
;
Jin-Hu ZHANG
Author Information
1. 中国医学科学院北京协和医学院阜外心血管病医院
- Keywords:
Hypertension,pulmonary;
Respiratory function tests;
Pulmonary diffusing capacity
- From:
Chinese Journal of Cardiology
2008;36(1):3-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the diagnostic value of pulmonary function testing in Chinese patients with known pulmonary arterial hypertension (PAH) without history of lung/heart valve diseases.Methods Pulmonary function testing was performed in 41 PAH patients diagnosed by right heart catheterization and in 17 healthv controls.Resuits Normal pulmonary function testing results were found in 5 PAH patients(12.2%).Total lung capacity,vital capacity and FEV1 were significantly decreased in PAH patients[(80.27±11.46)%vs.(94.24±6.82)%;(79.09±14.89)%vs.(97.35±9.51)%;(75.40±16.58)%vs.(95.12±12.01)%,respectively,all P＜0.001],the ratio of residual volume/total lung capacity was significantly increased[(117.67±25.73)%vs.(93.39±10.87)%,P＜0.001]:FEV1/FVC and maximal expiratory flow of 25% to 75% tended to be lower(-6.0% and -19.4%.P=0.21 and 0.09)while DLC0 and DLCO/VA were significantly decreased by 36.6%and 29.8%(P＜0.001)compared with healthy controls.Conclusions Increased peripheral airway obstruction and normal lung resistance were found in these PAH patients.Normal pulmonary function testing results could not rule out the diagnosis of PAH.
