Circadian rhythm of melatonin and blood pressure changes in patients with essential hypertension.
- Author:
Hong-Wei CUI
1
;
Zhong-Xia ZHANG
;
Ming-Tong GAO
;
Yu LIU
;
Ai-Hua SU
;
Mei-Ying WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Blood Pressure; physiology; Case-Control Studies; Circadian Rhythm; Female; Humans; Hypertension; physiopathology; urine; Male; Melatonin; urine; Middle Aged
- From: Chinese Journal of Cardiology 2008;36(1):20-23
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the association between melatonin (MLT) secretion and blood pressure changes during 24 hours in hypertensive patients (HPT) with (dipping) or without (non-dipping) night time blood pressure reduction.
METHODSThe 24-hour blood pressure and urine 6-SMT (6-sulfatoxymelatonin, metabolism product of MLT in urine) in the daytime and nighttime were measured in normal control subjects (n = 20), non-dipping HPT group (n = 32) and dipping HPT group (n = 36).
RESULTSAs expected, blood pressure reduction during the night was significantly lower in non-dipping HPT group compared to control and dipping HPT groups. Nighttime 6-SMT was significantly higher than daytime 6-SMT in all groups and nighttime urine 6-SMT levels and ratio of nighttime/daytime urine 6-SMT levels were significantly lower in non-dipping HPT group compared to control and dipping HPT groups (all P < 0.01). Moreover, ratio of nighttime/daytime urine 6-SMT levels are positively correlated blood pressure reduction during nighttime (P < 0.05) in all groups.
CONCLUSIONSCircadian rhythm of MLT secretion is maintained but nighttime MLT secretion was significantly reduced and related to disorders of circadian rhythm of blood pressure in non-dipping HPT group.