Circadian rhythm of melatonin and blood pressure changes in patients with essential hypertension
10.3321/j.issn:0253-3758.2008.01.006
- VernacularTitle:褪黑素与血压昼夜节律的相关性研究
- Author:
Hong-Wei CUI
1
;
Zhong-Xia ZHANG
;
Ming-Tong GAO
;
Yu LIU
;
Ai-Hua SU
;
Mei-Ying WANG
Author Information
1. 潍坊医学院附属医院
- Keywords:
Melatonin;
Blood pressure;
Circadian rhythm
- From:
Chinese Journal of Cardiology
2008;36(1):20-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the association between melatonin(MLT)secretion and blood pressure changes during 24 hours in hypertensive patients (HPT) with (dipping) or without (non-dipping)night time blood pressure reduction.Methods The 24-hour blood pressure and urine 6-SMT(6-sulfatoxymelatonin,metabolism product of MLT in urine) in the daytime and nighttime were measured in normal control subjects (n=20),non-dipping HPT group (n=32) and dipping HPT group (n=36).Results As expected,blood pressure reduction during the night was significantly lower in non-dipping HPT group compared to control and dipping HPT groups.Nighttime 6-SMT was significantly higher than daytime 6-SMT in all groups and nighttime urine 6-SMT levels and ratio of nighttime/daytime urine 6-SMT levels were significantly lower in non-dipping HPT group compared to control and dipping HPT groups (all P＜0.01).Moreover,ratio of nighttime/daytime urine 6-SMT levels are positively correlated blood pressure reduction during nighttime(P＜0.05)in all groups.Conclusions Circadian rhythm of MLT secretion is maintained but nighttime MLT secretion was significantly reduced and related to disorders of circadian rhythm of blood pressure in non-dipping HPT group.
