Incidence of metabolic disorders in patients with essential hypertension and patients with primary aldosteronism

VernacularTitle:原发性醛固酮增多症与原发性高血压代谢异常的比较
Author: Yan-Chun GONG ¹ ; Rui-Min GUO ; Shao-Xing CHEN ; Shao-Li CHU ; Ji-Zhen GUO ; Ding-Liang ZHU
Author Information

1. 上海交通大学医学院附属瑞金医院
Keywords: Hyperaldosteronism; Hypertension; Metabolic syndrome X
From: Chinese Journal of Cardiology 2008;36(2):128-131
CountryChina
Language:Chinese
Abstract: Objective To compare the incidence of metabolic disorders(MS)in patients with primary aldosteronism(PA)and essential hypertension(EH).Methods MS prevalence was observed in 200 EH patients(male 104)and 220 PA patients(male 117)hospitalized to our hospital from August 2005 to March 2007.Results (1)The prevalence of MS in PA group was significantly higher than that of EH group(47.3％vs.31.5％,P=0.009).(2)Blood pressure was significantly higher in PA group than that of EH[SBP:(150.67±15.45)mm Hg vs.(145.69±17.13)mm Hg,P=0.042;DBP:(93.03±10.51)mm Hg vs.(85.83±14.44)mm Hg,P=0.037].(3)Incidences of abdominal obesity(86.8％vs.78.5％,P=0.024)and insulin resistance(insulin sensitivity index:42.42±16.11 vs.49.58±22.43,P=0.008)were significantly higher in PA group than in EH group.Conclusion The prevalence of MS in hospitalized PA patients was significantly higher than that of EH patients characterized by prevalent abdominal obesity,insulin resistant and severe hypertension.