Transcatheter pulmonary valve replacement in sheeps:6-month evaluation of self-expanding valved stents
10.3321/j.issn:0253-3758.2008.02.013
- VernacularTitle:开胸经导管植入带瓣膜支架置换肺动脉瓣的实验观察
- Author:
Gang-Jun ZONG
1
;
Yuan BAI
;
Yong-Wen QIN
;
Hai-Bin JIANG
;
Hao ZHANG
;
Ying-Long YAO
;
Yi-Qing ZOU
;
Xian-Xian ZHAO
;
Hong WU
;
Xin-Miao HUANG
Author Information
1. 第二军医大学附属长海医院
- Keywords:
Cardiac surgical procedures;
Heart catheterization;
Pulmonary valve;
Stents
- From:
Chinese Journal of Cardiology
2008;36(2):151-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of this study was to determine the feasibility of transcatheter pulmonary valve replacement in sheeps up to 6 months post procedure.Methods Fresh sheep pericardium treated with a 0.6％glutaraldehyde solution for 36 hours Was sutured to a valvular ring and then fixed onto a newly designed nitinol self-expandable stent.Thoracotomy Was performed in sheeps(23.5±3.1)kg under general anesthesia and the device was delivered into the native pulmonary valve of the sheeps via the anterior wall of right ventricle by catheter and fooled for 6 months.Results One sheep died 4 months after the procedure due to in-stent thrombosis.Another 4 animals survived the 6-month observing period.Angiographic and hemodynamic measurements confirmed good positioning and function of the stents with a competent valve immediately post procedure and 6 months post the procedure in surviving animals.Conclusion Implantation of the nitinol self-expandable stent in the pulmonary valve position by a transcatheter approach is feasible and good function of transcatheter implanted memory nitinol valved stents was shown after 6 months of implantation in sheeps.
