Prevalence of anti-endothelial cell antibodies in patients with pulmonary arterial hypertension associated with connective tissue diseases.
- Author:
Meng-Tao LI
1
;
Jun AI
;
Zhuang TIAN
;
Quan FANG
;
Wen-Jie ZHENG
;
Xue-Jun ZENG
;
Xiao-Feng ZENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Autoantibodies; blood; immunology; Cell Line; Connective Tissue Diseases; blood; immunology; pathology; physiopathology; Endothelial Cells; cytology; immunology; Female; Humans; Hypertension, Pulmonary; blood; immunology; pathology; physiopathology; Middle Aged
- From: Chinese Medical Sciences Journal 2010;25(1):27-31
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the prevalence of anti-endothelial cell antibodies (AECAs) in the sera of connective tissue diseases (CTD) patients with pulmonary arterial hypertension (PAH) and its correlation with clinical manifestations.
METHODSAECAs in sera of 39 CTD patients with PAH, 22 CTD patients without PAH, and 10 healthy donors as controls were detected with Western blotting. The prevalence of different AECAs in different groups was compared and its correlation with clinical manifestations was also investigated.
RESULTSThe prevalence of AECAs was 82.1% in CTD patients with PAH, 72.7% in CTD patients without PAH, and 20.0% in healthy donors. Anti-22 kD AECA was only detected in CTD patients with PAH (15.4%). Anti-75 kD AECA was more frequently detected in CTD patients with PAH than in those without PAH (51.3% vs. 22.7%, P < 0.05). In CTD patients with PAH, anti-75 kD AECA was more frequently detected in those with Raynaud's phenomenon or with positive anti-RNP antibody.
CONCLUSIONAECAs could be frequently detected in CTD patients with or without PAH, while anti-22 kD and anti-75 kD AECA might be specific in CTD patients with PAH.
