Erythropoietin receptor positive circulating progenitor cells and endothelial progenitor cells in patients with different stages of diabetic retinopathy.
- Author:
Liu-mei HU
1
;
Xia LEI
;
Bo MA
;
Yu ZHANG
;
Yan YAN
;
Ya-lan WU
;
Ge-zhi XU
;
Wen YE
;
Ling WANG
;
Guo-xu XU
;
Guo-tong XU
;
Li WEI-YE
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Cell Count; Diabetes Mellitus, Type 2; complications; Diabetic Retinopathy; pathology; Endothelium, Vascular; cytology; Erythropoietin; blood; Female; Humans; Male; Middle Aged; Receptors, Erythropoietin; analysis; Stem Cells; physiology
- From: Chinese Medical Sciences Journal 2011;26(2):69-76
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the possible involvement of erythr opoietin (EPO)/erythropoietin receptor (EPOR) system in neovascularization and vascular regeneration in diabetic retinopathy (DR).
METHODSEPOR positive circulating progenitor cells (CPCs: CD34(+)) and endothelial progenitor cells (EPCs: CD34(+)KDR(+)) were assessed by flow cytometry in type 2 diabetic patients with different stages of DR. The cohort consisted of age- and sex-matched control patients with out diabetes ( n=7),non-proliferative DR (NPDR, n=7),non-proliferative DR (PDR, n=8), and PDR complicated with diabetic nephr opathy (PDR-DN, n=7).
RESULTSThe numbers of EPOR(+) CPCs and EPOR(+) EPCs were reduced remarkably in NPDR compared with the control group (both Pü0.01), whereas rebounded in PDR and PDR-DN groups in varyingdegrees. Similar changes were observed in respect of the proportion of EPOR(+)CPCs in CPCs (NPDR vs. control, Pü0.01) and that of EPOR(+) EPCs in EPCs (NPDR vs. control, Pü0.05).
CONCLUSIONExogenous EPO, mediated via the EPO/EPOR system of EPCs, may alleviate the impaired vascular regeneration in NPDR, whereas it might aggravate retinal neovascularization in PDR due to a rebound of EPOR(+)EPCs associated with ischemia.
