OBJECTIVETo investigate the value of neutrophil-monocyte product (NMP) combined with serum creatinine (Scr) in the assessment of the severity of acute pancreatitis (AP).

METHODSThe clinical data of 120 Uighur patients with AP were retrospectively analyzed, including 104 with non-severe AP (non-SAP group) and 16 with severe AP (SAP group). The correlation of NMP combined with Scr with ICU admission and in-hospital death were analyzed. The receiver operating characteristic (ROC) curves were plotted to compare the efficiency of acute physiology and chronic health evaluation (APACHE-II), neutrophil-lymphocyte ratio (NLR) and NMP combined with Scr in determining the severity of AP.

RESULTSThe levels of NMP and Scr were significantly higher in SAP group than in non-SAP group within 24 h after admission (P=0.012; P<0.001). NMP combined with Scr was positively correlated with ICU admission (r=0.489, P<0.001) and in-hospital death (r=0.383, P<0.001). No significant difference was found in the area under curve (AUC) between APACHE-II and NMP combined with Scr for determining AP severity (Z=0.38, P=0.704), but they both were superior to NLR (Z=3.10, P=0.002; Z=2.43, P=0.016).

CONCLUSIONNMP combined with Scr can be a simple and effective indicator for determining the severity of AP.