A systematic review of anti-interleukin-17 antibody in the treatment of plaque psoriasis.
- Author:
Xiao-Dong FAN
1
;
Xiang XIA
;
Chun-Yan ZHANG
;
Wen-Qiang KONG
;
Chun-Yang ZHOU
;
Biao DU
Author Information
- Publication Type:Journal Article
- From: Journal of Southern Medical University 2017;37(9):1274-1279
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy and safety of anti-interleukin-17 antibody in the treatment of plaque psoriasis.
METHDOSRandomized controlled trials (RCT) of anti-interleukin-17 antibody (Secukinumab, Brodalumab, and Ixekizumab) in the treatment of plaque psoriasis published between January, 2000 and March, 2017 were searched from PubMed, Cochrane Library, EBSCO, EMbase, CBM, CNKI, VIPdetabase, and Wangfang database. The quality of the retrieved trials was evaluated and the results of studies were analyzed using RevMan 5.0 software.
RESULTSThirteen RCTs were included involving a total of 11 203 patients. Meta-analysis showed a significant differences between anti-interleukin-17 antibody and placebo (or positive drug) in terms of PASI75 and sPGA (P<0.05). The total incidence of adverse events differed significantly between anti- interleukin-17 antibody and placebo, but no significant differences were found between them in the incidence of serious adverse events and discontinuation rate due to adverse events (P>0.05).
CONCLUSIONAnti-interleukin-17 antibody is safe and effective for treatment of plaque psoriasis.
