Clinical Significance of Plasma TGF-β1 in Coal Workers' Pneumoconiosis.
10.4046/trd.2001.50.1.76
- Author:
Chong Ju KIM
;
Won Yeon LEE
;
Ae Ra HONG
;
Pyo Jin SHIN
;
Suk Joong YONG
;
Kye Chul SHIN
- Publication Type:Original Article
- Keywords:
Coal workers' pneumoconiosis;
TGF-β1;
Pulmonary fibrosis
- MeSH:
Cicatrix;
Coal*;
Collagen;
Dust;
Enzyme-Linked Immunosorbent Assay;
Extracellular Matrix Proteins;
Fibroblasts;
Fibrosis;
Humans;
Inhalation;
Lung;
Lung Diseases;
Plasma*;
Pneumoconiosis*;
Pulmonary Fibrosis
- From:Tuberculosis and Respiratory Diseases
2001;50(1):76-83
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Coal workers' pneumoconiosis is a fibrotic lung disease resulting from chronic inhalation of coal dust. The precise mechanism of lung fibrosis in coal workers' pneumoconiosis is uncertain. However, a relationship between the stimulation of fibroblast proliferation and collagen production by mediators released from inflammatory and resident lung cells is thought to be a major factor. The transforming growth factor-β(TGF-β), a multifunctional cytokine and growth factor, plays a key role in the scarring and fibrotic processes due to its ability to induce extracellular matrix proteins and modulate the growth and immune function of many cell types. To determine the involvement of TGF-βin the development of lung fibrosis in coal workers' pneumoconiosis, the TGF-β1 level in plasma was measured in patients with coal workers' pneumoconiosis. METHODS: Plasma was collected from 40 patients with coal workers' pneumoconiosis (20 with simple coal workers' pneumoconiosis and 20 with complicated coal workers' pneumoconiosis) and from 10 normal controls. The ELISA method was used to measure the plasma TGF-β1 concentration. RESULTS: Compared to the control group (0.63±0.18 ng/mL), there was no significant difference in the plasma TGF-β1 level in patients with simple coal workers' pneumoconiosis (0.64±0.17 ng/mL) (p>.05). However, in patients with complicated coal workers' pneumoconiosis the plasma TGF-β1 level (0.79±0.18 ng/mL) was significantly higher than in patients with simple coal workers' pneumoconiosis and control group (p<0.05). CONCLUSION: The data suggests that TGF-β1 has some influence in the development of lung fibrosis in coal workers' pneumoconiosis.
