Polymorphism of alcohol metabolizing-related enzyme genes and its correlation with drinking-behaviors in 201 cases of Chinese Han healthy population.
- Author:
Xi-rong CAO
1
;
De-sheng WU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Alcohol Drinking; ethnology; genetics; physiopathology; Aldehyde Dehydrogenase; genetics; metabolism; Aldehyde Dehydrogenase, Mitochondrial; Asian Continental Ancestry Group; genetics; China; Drinking Behavior; Ethanol; metabolism; Female; Gene Frequency; Genetic Predisposition to Disease; ethnology; Genotype; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Surveys and Questionnaires; Young Adult
- From: Chinese Journal of Preventive Medicine 2005;39(2):84-87
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the distribution of genotypes about alcohol dehydrogenase 2 (ADH2) and aldehyde dehydrogenase 2 (ALDH2) and its relationship with drinking-behaviors in Chinese Han healthy population as to providing a theoretic direction for filtering out high-risk and sensitive individuals and taking preventive measures to decrease the alcohol-related diseases.
METHODSUsing questionnaires to select subjects (201 persons, including men 104, women 97) for collecting blood samples and data about drinking-behaviors. Techniques of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) were used to detect the genotypes of ADH2 and ALDH2.
RESULTSHeterozygous ADH2 and homozygous ALDH2 were the two dominant ones (respectively 53.23%, 68.16%). There were no statistical differences among the distributions of nine combinations of ADH2 genotypes and ALDH2 ones. The difference of distribution of homozygous ALDH2 between males having high and middle drinking-frequencies seemed to be statistically meaningful.
CONCLUSIONThe proportion of individuals carrying about "susceptible genotypes of alcohol-related diseases" in Chinese Han healthy population should be more than one half (68.16%), which calls on reinforcing the surveillance and preventing the alcohol-related diseases. Correlation between genotypes of ADH2 and ALDH2 and alcohol-related diseases should be more important.
