Progress in the study of multidrug and toxin extrusion proteins.
- Author:
Yuan-Yuan YANG
;
Yue-Ming MA
- Publication Type:Journal Article
- MeSH:
Animals;
Biological Transport;
Cations;
Organic Cation Transport Proteins;
metabolism;
Polymorphism, Genetic
- From:
Acta Pharmaceutica Sinica
2014;49(8):1105-1110
- CountryChina
- Language:Chinese
-
Abstract:
Mammal multidrug and toxin extrusion proteins (MATEs) play an important role in the transport of organic cations in the body. MATEs mediate the final excretion step for multiple organic cation drug used clinically and important endogenous substances. This article reviews the discovery, type, gene coding and polymorphism, body distribution, classification of substrates and inhibitors and their research method of MATEs. The article also discusses the major research significance of MATEs with examples.
