Potential targets for anti-liver fibrosis.
- Author:
Shuang-shuang ZHAO
1
;
Rong-guang SHAO
;
Hong-wei HE
Author Information
1. Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
- Publication Type:Journal Article
- MeSH:
Collagen;
metabolism;
Humans;
Integrin alphaV;
metabolism;
Liver;
pathology;
Liver Cirrhosis;
drug therapy;
Transforming Growth Factor beta1;
metabolism
- From:
Acta Pharmaceutica Sinica
2014;49(10):1365-1371
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is a pathological process of the excessive accumulation of extracellular matrix, especially collagen al (I) in liver. Ultimately, hepatic fibrosis leads to cirrhosis or hepatic failure. Liver fibrosis and early cirrhosis can be reversed, thus control of the development of liver fibrosis is very important for preventive treatment of cirrhosis and hepatic failure. This is a review of potential targets for anti-hepatic fibrosis based on plenty of publications, including TGF-β1 and integrin α(v) and so on, aimed at providing novel therapeutic targets in liver fibrosis.
