Two new sulfated sesquiterpenoids from Petasites tricholobus.
- Author:
Yong ZHANG
1
;
Yuan-Yuan GAO
;
Qi JIA
;
Fu-Jiang GUO
;
Bo LI
;
Zhi-Jian XU
;
Yi-Ming LI
;
Wei-Liang ZHU
;
Kai-Xian CHEN
Author Information
1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
- Publication Type:Journal Article
- MeSH:
Cell Line, Tumor;
Glycosides;
isolation & purification;
pharmacology;
Humans;
Norisoprenoids;
isolation & purification;
pharmacology;
Petasites;
chemistry;
Sesquiterpenes;
isolation & purification;
pharmacology
- From:
Acta Pharmaceutica Sinica
2014;49(10):1433-1437
- CountryChina
- Language:English
-
Abstract:
Two new sulfated sesquiterpenoids, megastigman-7-ene-3, 5, 6, 9-tetrol-3-O-β-D-6'-sulfonated-glucopyranoside (1) and 3-O-β-D-6'-sulfonated-glucopyranosyl-6-(3-oxo-2-butenylidenyl)-1, 1, 5-trimethylcyclohexan-5-ol (2), along with one known sesquitepenoid compound icariside B1 (3) were isolated from the whole herb of Petasites tricholobus Franch. Their structures were identified by their chemical and spectroscopic characters. All obtained compounds were tested for their cytotoxicity against four cancer cell lines.
