Preparation and characterization of tumor targeted CdTe quantum dots modified with functional polymer.
- Author:
Hong-Yan ZHU
1
;
Jing-Ping ZHU
;
Ai-Mei XIE
;
Jing YUAN
;
Ye HUA
;
Wei ZHANG
Author Information
1. Nantong University, China.
- Publication Type:Journal Article
- MeSH:
Acetylcysteine;
chemistry;
Cadmium Compounds;
pharmacology;
Humans;
Neoplasms;
drug therapy;
Polymers;
chemistry;
Quantum Dots;
chemistry;
Spectrophotometry, Ultraviolet;
Tellurium;
pharmacology
- From:
Acta Pharmaceutica Sinica
2014;49(10):1457-1465
- CountryChina
- Language:Chinese
-
Abstract:
N-acetyl-L-cysteine (NAC) capped quantum dots (QDs) were synthesized by a hydrothermal method and coated with 2-amino-2-deoxy-D-glucose (DG), polyethylene glycol (PEG), and 9-D-arginine (9R). The optical properties, morphology and structure of 9R/DG-coated CdTe QDs were characterized by ultraviolet-visible spectrometry, fluorescence spectrum, Fourier transform infrared (FTIR), proton nuclear magnetic resonance (1H NMR), liquid chromatography-mass spectrometer (LC-MS), sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and transmission electron micrographs (TEM). Furthermore, the biocompatibility, tumor targeted ability and transmembrane action of 9R/DG-coated CdTe QDs were studied. Results indicated that 9R/DG-coated CdTe QDs was constructed successfully by ligand exchange. The 9R/DG-coated CdTe QDs with the size of 8-10 nm had good dispersity and the absorbance and fluorescence peaks of CdTe QDs after modification were red shifted from 480 nm to 510 nm and 627 nm to 659 nm, respectively. In addition, the CdTe QDs modified by PEG, DG and 9R displayed good biocompatibility, high targeted ability to the cancer cells with glucose transporter type 1 (GLUT1) receptor high expression and obvious transmembrane ability.
