Progress in the study of Velvet and LaeA proteins and their relation to the development and bioactive compounds in medicinal fungi.
- Author:
Zhi-chao XU
;
Chao SUN
;
Jiang XU
;
Xin ZHANG
;
Hong-mei LUO
;
Ai-jia JI
;
Yuan-lei HU
;
Jing-yuan SONG
;
Shi-lin CHEN
- Publication Type:Journal Article
- MeSH:
Fungal Proteins;
metabolism;
Fungi;
chemistry;
Gene Expression Regulation, Fungal;
Genes, Regulator;
Protein Structure, Tertiary;
Secondary Metabolism;
Structure-Activity Relationship
- From:
Acta Pharmaceutica Sinica
2014;49(11):1520-1527
- CountryChina
- Language:Chinese
-
Abstract:
The medicinal fungi, which are of great importance in traditional medicine, are facing the problems of wild resources scarcity and low concentration of bioactive compounds. Velvet family and LaeA global regulator play a vital role in secondary metabolism and developmental programs, which are found in a wide variety of fungi ranging from Chytridiomycota to Basidiomycota. This review elaborates the structures and functions between Velvet family and LaeA protein. The Velvet family which shares the Velvet protein domain, including VeA (Velvet), VelB (Velvet like B), VosA (viability of spores A) and VelC (Velvet like C), acts on the regulation function is secondary metabolism and developmental programs such as asexual and sexual development. Furthermore, the function is affected by environmental factors such as light and temperature. LaeA protein which owns S-adenosylmethionine-dependent methyltransferase domain, coordinately regulates development and secondary metabolism by regulating and modifying the Velvet proteins. The regulation of LaeA is mediated by light receptor proteins. Therefore, clarifying the mechanism of Velvet and LaeA proteins in medicinal fungi will pave the way for nurturing medicinal fungi and improving production of bioactive compounds.
