Distribution of Apo E gene sequencing in patients with coronary heart disease of phlegm-stasis syndrome.
- Author:
Zhu-yuan FANG
1
;
Wei-min JIANG
;
Chang-le ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Alleles; Apolipoproteins E; genetics; Base Sequence; Case-Control Studies; Coronary Disease; diagnosis; genetics; Female; Genotype; Humans; Male; Medicine, Chinese Traditional; Middle Aged
- From: Chinese Journal of Integrated Traditional and Western Medicine 2011;31(9):1201-1204
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the correlation between Apo E gene polymorphism and patients with coronary heart disease (CHD) of phlegm-stasis syndrome (PSS).
METHODS78 CHD patients were assigned to PSS (49 cases) and non-phlegm-stasis syndrome (NPSS). Polymorphisms of Apo E gene in 78 CHD patients and 100 healthy subjects were detected by complete DNA sequencing.
RESULTSFive gene types as E3/3, E4/4, E2/ 3, E2/4, and E3/4 were detected in the two groups. The frequencies of genotype E3/3 and epsilon 3 allele were significantly lower in CHD patients than in the healthy subjects (P<0.01). But the frequencies of genotype E3/4 and epsilon 4 allele were significantly higher in CHD patients than in the healthy subjects (P<0.01). In CHD patients, the frequencies of genotype E2/4 + E3/4 + E4/4 and epsilon 4 allele were higher in PSS than in NPSS.
CONCLUSIONSApo E epsilon 4 allele was a susceptible allele to CHD, which was closely correlated to CHD PSS. It was inferred that it might be one of main susceptible alleles for CHD PSS.
