Relationship between Helicobacter pylori seroprevanlence in children and history of digestive disorders in children and their parents
- Author:
Bang Van Nguyen
- Publication Type:Journal Article
- Keywords:
children;
helicobacter pylori infection;
history of digestive disorders;
seroprevalence
- MeSH:
Helicobacter pylori/ pathogenicity;
Stomach/ pathology;
Duodenal Diseases/ diagnosis;
pathology;
Child
- From:Journal of Medical Research
2007;55(6):141-145
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Background: The role of Helicobacter pylori live in digestive tract cause digestive disorder are confirmed. Objectives: To assess the relationship between seroprevalence of Helicobacter pylori (HP) in children and history of digestive disorders in children and their parents. Subjects and method: In this cross-sectional study, history of digestive disorders (recurrent epigastralgy at least 3 episodes in a duration at least 3 months, confirmed either by upper endoscopy or by gastric radiography with contrast or ameloration by treatment with anti - acid) was gathered using questionnaire with additional examination of individual health book, prescription or discharge certificate of a population of 818 children <15 years old in pediatric department, Bach Mai hospital and 369 children <18 in a rural commune. Seroprevalence was determined by ELISA with cut - off at 0.18 optic density. Results:Among in - patients, seroprevalence was 52.6% (20/38) in children with digestive history, significantly higher than 32.6% (254/780) in those who were without this history (p=0.013); risk for HP infection in children with the history was 4.8 higher than that in those who were without the history [OR (95% CI): 4.79 (1.62-9.16)), while the difference in HP seroprevalence was insignificant in children whose mother or father was with or without the history (p > 0.05). Among children in the community, the difference in HP seroprevalence of 72.7% (8/11) in children with and 55.0% (250/373) in those without the history was statistically insignificant (p>0.05). However, HP seroprevalence in children whose father or mother was with the history was of 71.8% (28/39) and 70.5% (31/44), respectivly, significantly higher than 43.1 % (94/318) and 45.6% (125/274) in those whose father or mother was without the history, respectively (p < 0.05). Risk for being HP seropositive in children whose father was with the history was 3.4 folds higher than those whose father was without the history [OR (95% CI): 3.36 (1.38-7.54)] and that in children whose mother was with the history was 2.9 folds higher than in those whose mother was without the history [OR (95% CI): 2.91 (1.41-5.26)]. Conclusion: It exsisted a discrepancy in relationship between HP seroprevalence in children and history of digestive disorders in 2 groups of population in the hospital and in the community, and further studies with larger size were warranted to better clarify this relationship.
