Diagnosis of recurrent or residual nasopharyngeal carcinomas in the skull base area with F-18-fluoro-deoxyglucose positron emission tomography.
- Author:
Liang ZENG
1
;
Xiao-Ming HUANG
;
Tai-Xiang LU
;
Yi-Qing ZHENG
;
Qiu-Jian CHEN
;
Yong CHEN
;
Sui-Qiao HUANG
;
Wei SUN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; False Positive Reactions; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Nasopharyngeal Neoplasms; diagnostic imaging; drug therapy; radiotherapy; Positron-Emission Tomography; methods; Skull Base; diagnostic imaging
- From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2006;41(7):517-520
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the diagnostic value of F-18-fluoro-deoxyglucose positron emission tomography (FDG-PET) for the recurrent or residual nasopharyngeal carcinomas in the skull base area.
METHODSNine post-irradiation nasopharyngeal carcinoma patients did FDG-PET scanning, CT/MRI imaging and underwent nasopharynx and skull base-biopsy under endoscopy. The results of FDG-PET were evaluated and compared with CT/MRI studies and biopsies.
RESULTSIn 9 cases of post-irradiation nasopharyngeal carcinoma, CT/MRI detected 7 recurrent cases and 2 suspected recurrent cases in occipital bone and clivus. All 9 cases had accumulated FDG in nasopharynx and cranial base. A definite diagnosis was made by biopsy, 3 cases were confirmed recurrence, and others 6 cases were proved mucous chronic inflammation and (or) osteoradionecrosis. The accuracy of FDG-PET was 33.3% (3/9), and the false positive rate was 66.7% (6/9).
CONCLUSIONSDiagnosis of recurrent or residual nasopharyngeal carcinomas in the skull base area with FDG-PET had high false-positive rate, final diagnosis must depend on histopathologic examination under endoscopy.
