Experimental study on facial nerve regeneration by porous silk fibroin conduit.
- Author:
Yan LU
1
;
Fang-lu CHI
;
Xia ZHAO
;
Zhen-zhong SHAO
;
Zheng-bing CAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Facial Nerve Injuries; surgery; Female; Fibroins; pharmacology; therapeutic use; Materials Testing; Nerve Regeneration; drug effects; Rats; Rats, Sprague-Dawley; Wound Healing
- From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2006;41(8):603-606
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the feasibility of using polyporus silk fibroin as a kind of novel material for facial nerve regeneration.
METHODSThe porous silk fibroin conduit was used in the reconstruction of a 5 mm facial nerve gap of SD rat. Chitosan conduit was taken as control group. General observation, electrophysiological study, histological study and image analysis were performed 2, 4, 6 and 8 weeks postoperatively.
RESULTSThe facial nerve of SD rat regenerated successfully as time passed through. Mean CAP percentage of regenerated nerve in SF conduit was 24.94% +/- 5.73% 8 weeks postoperatively, which had no statistical significance with that of chitosan conduit group (P = 1.125). And the average number of myelinated myelinated nerve fibers in SF conduit was 62. 5 +/- 6. 3, which had statistical significance with that in chitosan conduit group (P = 0.016).
CONCLUSIONSThe porous silk fibroin conduit could effectively repair facial nerve defect and improve peripheral nerve functional recovery.
