Hemocompatibility of bovine pericardium with additional sodium bisulfite treatment.
- Author:
Mao-sheng HAN
1
;
Jian-ye ZHOU
;
Sheng-shou HU
;
Sheng WANG
;
Hong JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Biocompatible Materials; Bioprosthesis; Blood Coagulation; Cattle; Complement C3a; analysis; Fibrin Fibrinogen Degradation Products; metabolism; Glutaral; pharmacology; Materials Testing; Pericardium; drug effects; metabolism; Platelet Adhesiveness; Sulfites; pharmacology
- From: Acta Academiae Medicinae Sinicae 2007;29(5):638-641
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the hemocompatibility of glutaraldehyde (GA)-tanned bovine pericardium additionally treated by sodium bisulfite (SOB) solution.
METHODSThe hemocompatibility of GA-tanned bovine pericardium treated by SOB solution is evaluated by using dynamic clotting time test, blood platelet adhension test, D-dimeride determination, and complement activation test. The GA-tanned bovine pericardium was used as control.
RESULTSThe curve of absorbance-clotting time of two kinds of bovine pericardium was similar in dynamic clotting time test. There was no significant difference between SOB-treated and control groups in blood platelet adhension test. The D-dimeride contents of all bioprostheses were at normal level, and the D-dimeride content of GA-tanned bovine pericardium treated by SOB solution was significantly lower than that of control group (P < 0.05). In complement activation test, the level of complement C3a in SOB-treated group was significantly lower than that in control group (P < 0.05).
CONCLUSIONGA-tanned bovine pericardium treated by SOB solution meets the demands of cardiac interstitial implanted materials in hemocompatibility.
