Expression of melanoma antigen-1, 3 genes in human intrahepatic cholangiocarcinoma and its clinical significance.
- Author:
Xin LU
1
;
Hai-Tao ZHAO
;
Xin-Ting SANG
;
Yi-Lei MAO
;
Rong-Rong CHEN
;
Shou-Xian ZHONG
;
Jie-Fu HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Antigens, Neoplasm; genetics; Bile Duct Neoplasms; genetics; Bile Ducts, Intrahepatic; pathology; Cholangiocarcinoma; genetics; Female; Humans; In Vitro Techniques; Liver Neoplasms; genetics; Male; Melanoma-Specific Antigens; Middle Aged; Neoplasm Proteins; genetics; Reverse Transcriptase Polymerase Chain Reaction
- From: Acta Academiae Medicinae Sinicae 2008;30(2):197-200
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the possibility of using melanoma antigen (MAGE)-1 and MAGE-3 gene encoding proteins as an index of potential target for immunotherapy in intrahepatic cholangiocarcinoma (IHCC) patients.
METHODSThe expressions of MAGE-1 and MAGE-3 genes in tumor tissues and tumor adjacent non-IHCC liver tissues were examined by RT-PCR method. The relationship between positive expression rates of MAGE-1 and MAGE-3 genes and clinical data including sex, age, tumor diameters, tumor envelope, tumor nodules number, and hepatitis B virus surface antigen were determined.
RESULTSThe positive expression rates of MAGE-1 (35%) and MAGE-3 genes (45%) were significantly higher in the tumor tissues than in tumor adjacent tissues (0) (P<0.01). The positive expression rates of MAGE-1 and MAGE-3 genes had no relationship with the clinical data (P >0.05), except the morphology of tumor (P <0.05).
CONCLUSIONThe high expression rates of MAGE-1 and MAGE-3 genes in IHCC suggests the MAGE-1 and MAGE-3 gene may be a target for immunotherapy in IHCC patients.
