Recent Advances in Skeletal Muscle Stem Cells for Duchenne Muscular Dystrophy Treatment.
10.7599/hmr.2015.35.4.222
- Author:
Jin Young YANG
1
;
Jaemin JEONG
Author Information
1. Department of Surgery, Hanyang University College of Medicine, Seoul, Korea. jmj1103@hanyang.ac.kr
- Publication Type:Clinical Trial ; Review
- Keywords:
Satellite Cells, Skeletal Muscle;
Muscular Dystrophy, Duchenne;
Dystrophin;
Clinical Trial
- MeSH:
Dystrophin;
Mesenchymal Stromal Cells;
Muscle Proteins;
Muscle, Skeletal*;
Muscular Dystrophies;
Muscular Dystrophy, Duchenne*;
Regeneration;
Satellite Cells, Skeletal Muscle;
Stem Cells*
- From:Hanyang Medical Reviews
2015;35(4):222-228
- CountryRepublic of Korea
- Language:English
-
Abstract:
Muscle stem cells, which are known as satellite cells have heterogeneous components of committed myogenic progenitors, non-committed satellite cells, and mesenchymal stem cells. This distinguishing organization of self-renewal and differentiation capacities encourages the remarkable regenerative ability of skeletal muscles. Lately it has been proved that the satellite cell is the derivation of muscle regeneration and with the self-renew function, it roles as a true muscle stem cell. Therefore, stem cell therapy using satellite cells is considered to be ideal therapy for muscular dystrophies, which is deficient in specific muscle protein and causes muscle degeneration. Especially, Duchenne Muscular Dystrophy (DMD), which is caused by mutations at the dystrophin gene, has been targeted by much research. In this article the satellite cell characteristics, regulation of cell function, and stem cell therapy for DMD and the present progressive clinical trials will be reviewed.
