Lung cancer diagnosis based on urinary modified nucleoside metabolic profiling.
- Author:
Wen-Zhao WANG
1
;
Xin-Jie ZHAO
;
Xiang LI
;
Jing CHEN
;
Fang-Lou LI
;
Guo-Wang XU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Biomarkers; urine; Humans; Least-Squares Analysis; Lung Neoplasms; diagnosis; urine; Metabolome; Models, Biological; Nucleosides; urine
- From: Acta Academiae Medicinae Sinicae 2007;29(6):738-741
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the feasibility of modified urinary nucleosides metabolic profiling on lung cancer diagnoses.
METHODSThe modified urinary nucleosides metabolic profiling from 42 normal adults and 80 patients with lung cancer were determined by a coupled-column high performance liquid chromatography system. Partial least squares-discriminant analysis (PLS-DA) models were used to class differentiation between the lung cancer patients and controls and to discover potential biomarkers.
RESULTThe PLS-DA model results showed that there was a clear differentiation between normal adults and lung cancers patients, with the value of prediction (Q2) equals to 0.744.
CONCLUSIONModified urinary nucleosides metabolic profiling method is useful for lung cancer diagnoses.
