Efficacy of monotherapy with 15 antihypertensive agents in treating essential hypertension assessed by 24-hour ambulatory blood pressure monitoring.
- Author:
Cong-Xiao HUA
1
;
Lu HUA
;
Na LI
;
Li WANG
;
Hui-Min PANG
;
Guang-Hua MING
;
Yan HUANG
;
Xiao-Ru CHENG
;
Hong LIU
;
Ying WU
;
Li XU
;
Jian KANG
;
Zhi-Min XU
;
Yi-Shi LI
Author Information
- Publication Type:Journal Article
- MeSH: Adrenergic beta-Antagonists; therapeutic use; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; therapeutic use; Antihypertensive Agents; classification; therapeutic use; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; therapeutic use; Doxazosin; therapeutic use; Drug Therapy, Combination; Humans; Hypertension; drug therapy; Prazosin; analogs & derivatives; therapeutic use; Sulfonamides; therapeutic use; Treatment Outcome
- From: Acta Academiae Medicinae Sinicae 2007;29(6):792-796
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy of the monotherapy of 15 agents in treating essential hypertension.
METHODSAfter 2-week wash-out, a total of 370 patients with seated diastolic blood pressure 95-114 mmHg and seated systolic blood pressure < 180 mmHg were randomized to different therapeutic groups. 24-hour ambulatory blood pressure monitoring was performed before medication and at the end of 8 weeks.
RESULTAll the agents significantly reduced the 24 hour mean blood pressures after treatment except doxazosin, terazosin, and torasemide.
CONCLUSIONThe result suggested that the angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta-blockers and long-acting calcium antagonists were effective in treating essential hypertension, while the low-dose doxazosin, terazosin and torasemide can be used for combination therapy but not for monotherapy.
