Expression of Pigment Epithelium-derived Factor in Bladder Tumour Is Correlated with Interleukin-8 yet Not with Interleukin-1α
10.1007/sl1596-011-0144-6
- Author:
FENG CHENCHEN
1
;
GUAN MING
;
DING QIANG
;
ZHANG YUANFANG
;
JIANG HAOWEN
;
WEN HUI
;
WANG PAOHSUN
;
WU ZHONG
Author Information
1. Department of UrologyHuashan Hospital, Fudan University,Shanghai 200040,China
- Keywords:
angiogenesis;
bladder tumour;
interleukin-1α;
interleukin-8;
pigment epithelium-derived factor
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2011;31(1):21-25
- CountryChina
- Language:Chinese
-
Abstract:
Pigment epithelium-derived factor (PEDF) is an antiangiogenic factor which is effective in tumour inhibition in a variety of tumours and has not yet been studied in bladder tumour before.In this study the expression of PEDF,interleukin-1 α (IL-1α) and -8 (IL-8) in bladder tumours was investigated.Immunohistochemistry was performed on 64 bladder tumour and 23 normal uroepithelium samples.Expression change of the factors was compared with clinicopathological parameters.Correlations between PEDF,IL-1α and IL-8 were analyzed.None of the factors was in relation to gender,tumour occurrence,and size or onset pattem.PEDF (P=0.014) and IL-1α (P=0.049) expression was down-regulated with grade progression.PEDF expression was lower in normal uroepithelium than in papillary urothelial neoplasm of low malignant potential (PUNLMP) (P=0.000) and carcinoma (P=0.009) whilst IL-1α (P=0.000 and P=0.000 respectively) and IL-8 (P=0.000 and P=0.023 respectively) expression was higher in the same grouping.PEDF expression had a negative correlation with IL-8 in PUNLMP (P=0.049,r=-0.578) as well as in tumour grouping (P=0.033,r=-0.276).Deranged expressional change of PEDF,IL-1 α and IL-8 could be in relation to loss of differentiation from normal uroepithelium to papillary lesion and eventually to carcinoma.
