Lack of Association of Common Polymorphism of LRP1 Gene with Myocardial Infarction in a Chinese Han Population
10.1007/sl1596-011-0370-y
- Author:
REN HONGGANG
1
;
GUO TAO
;
WANG HUAFANG
;
SUN CHUNYAN
;
ZHANG XIAOPING
;
MEI HENG
;
HU YU
Author Information
1. Institute of Hematology and the Ministry of Education Key Lab of Targeted Biotherapy, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430022, China
- Keywords:
low-density lipoprotein receptor-related proteinl;
myocardial infarction;
polymorphism
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2011;31(3):295-300
- CountryChina
- Language:Chinese
-
Abstract:
This study examined the association of a common polymorphic allele (25G) of the low-density lipoprotein receptor-related proteinl (LRP1) gene with myocardial infarction (MI).The genotypes of LRP1 25CG (rs35282763) were determined in 347 MI patients and 347 age-and sex-frequency-matched controls from an unrelated Chinese Han population.Factor Ⅷ (FⅧ) levels were measured in the MI patients and controls by chromogenic assay and enzyme-linked immunosorbent assay (ELISA).The results showed that LRP1 25CG (rs35282763) genotype distribution did not differ significantly between patients (n=206 for 25CC,n=122 for 25CG) and controls (n=191 for 25CC,n=126 for 25CG;P＞0.05).The 25G allele was not associated with a reduced risk of MI (P ＞0.05).Further stratifications for age,sex,and other cardiovascular risk factors did not affect the negative findings.It was concluded that the presence of the G allele at the 25CG (rs35282763) polymorphism of the LRP1is not associated with a reduced risk of MI,and genotyping for LRP1 25CG (rs35282763) polymorphism is not useful in assessing the individual risk of MI.
