Association of Polymorphisms in Angiotensin Ⅱ Receptor Genes with Aldosterone-producing Adenoma
10.1007/sl1596-011-0371-x
- Author:
OUYANG JINZHI
1
;
WU ZHUN
;
XING JINCHUN
;
YAN YONGJI
;
ZHANG GUOXI
;
WANG BAOJUN
;
LI HONGZHAO
;
MA XIN
;
ZHANG XU
Author Information
1. Department of Endocrinology,Chinese PLA General Hospital, Beijing 100086, China
- Keywords:
aldosterone-producing adenoma;
angiotensin Ⅱ receptor;
polymorphism
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2011;31(3):301-305
- CountryChina
- Language:Chinese
-
Abstract:
This study examined the association of polymorphisms in angiotensin Ⅱ receptor genes (AT1R and AT2R) with the risk for aldosterone-producing adenoma (APA) in a Chinese Han population.Four polymorphisms including rs5182 (573T/C) in exon 4,rs5186 (1166A/C) in 3'-untranslated region (3'-UTR) in AT1R gene and rs5194 (2274G/A) in 3'-UTR,rs1403543 (1675G/A) in intron 1 in AT2R gene were detected in 148 APA patients and 192 normal subjects (serving as control) by using a MGB-Taqman probe.The distribution of genotypes of each locus was in accordance with Hardy-Weinberg Equilibrium (HWE) in the APA and control groups (P＞0.05).The allele A frequency at rs5194 was significantly higher in the APA group (0.49) than in the control group (0.35) (X2=12.08,P=0.001).Subjects with homozygotic genotype AA and heterozygotic genotype GA were at an increased risk for APA as compared to those with GG genotype (OR=2.66,95％ CI=1.45-4.87; OR=1.67,95％ CI=1.02-2.74).Furthermore,rs5194 single-nucleotide polymorphism (SNP) at AT2R gene was significantly associated with APA in additive (OR=1.64,95％ CI=1.21-2.20,P=0.001),dominant (OR=1.94,95％ CI=1.23-3.06,P=0.003),and recessive model (OR=2.01,95％ CI=1.17-3.45,P=0.01).It was concluded that rs5194 polymorphism at AT2R gene was associated with the risk for APA,which may constitute a genetic marker of APA.
