Telmisartan Protects against Insulin Resistance by Attenuating Inflammatory Response in Rats
10.1007/sl1596-011-0374-7
- Author:
XU XIZHEN
1
;
YIN XIAOMING
;
FENG WENJING
;
LI GENG
;
WANG DAOWEN
;
TU LING
Author Information
1. Department of Internal Medicine and the Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
- Keywords:
telmisartan;
insulin resistance;
inflammation;
obesity
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2011;31(3):317-323
- CountryChina
- Language:Chinese
-
Abstract:
This study investigated the effects of telmisartan on insulin resistance in high-fat diet-treated rats and the possible mechanism.A total of 40 male Sprague-Dawley rats enrolled in the study were divided into 4 groups at random:ND group (n=10) and HD group (n=10),in which the rats were given a normal chow diet or a high-fat diet for 20 weeks following a one-week adaptation; ND+telmisartan (n=10) group and HD+telmisartan group (n=10),in which the rats were initially administered in the same way as the ND or HD group,and then they were orally gavaged with telmisartan (5 mg/kg daily)additionally for 5 weeks.Related inflammatory factors were measured by ELISA.Monocyte chemotactic protein 1 (MCP-1),phosphorylated JNK and Iκ B-α expressions in both adipose and liver were detected by Western blotting.CRP and angiotensin Ⅱ receptor 1 (AT1) mRNA expressions in both adipose and liver were determined by RT-PCR.The results showed that telmisartan administration in vivo reversed insulin resistance as evidenced by a decrease in plasma fasting glucose levels,plasma fasting insulin levels and homeostasis model of assessment-insulin resistance (HOMA-IR).Furthermore,telmisartan administration significantly reduced serum CRP,TNF-α and IL-1β levels,and elevated serum IL-10 levels.It was also found to hamper the high-fat diet-induced increase in CRP mRNA,AT1 mRNA and MCP-1,and decrease in Iκ B-α in both adipose and liver.It was concluded that telmisartan administration in vivo may improve insulin resistance through attenuated inflammatory response pathways.
