Effects of Variant rs346473 in ARHGAP24 Gene on Disease Progression of HBV Infection in Han Chinese Population
10.1007/sl1596-011-0477-1
- Author:
LIU LIFENG
1
,
2
;
YAO JINJIAN
;
LI JIN
;
ZHANG JINLIANG
;
YU JINLING
;
JIANG XIAORUI
;
SUN SHUZHEN
;
LIU QING
;
CHANG YING
;
HE YONGWEN
;
LIN JUSHENG
Author Information
1. Institute of Liver Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030,China
2. Liaocheng People's Hospital, Liaocheng 252000, China
- Keywords:
ARHGAP24 gene;
single nucleotide polymorphisms;
HBV progression
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2011;31(4):482-487
- CountryChina
- Language:Chinese
-
Abstract:
Host genetic,environmental and viral factors are classified as three categories that determine clinical outcomes of hepatitis B virus (HBV) infection.The objective of this study was to detect the associations between polymorphisms rs346473 and rs346482 in Rho GTPase-activating protein 24 (ARHGAP24) gene and disease progression of HBV infection in Han Chinese population.These two SNPs were found by our DNA pooling using Affymetrix Genome-Wide Human Mapping SNP6.0 Array in HBV carriers,and verified by using TaqMan 7900HT Sequence Detection System with 758 progressed HBV carriers versus 300 asymptomatic HBV carriers (AsC) in a discovery phase and 971 progressed HBV carriers versus 328 AsC in a replication phase.Multivariable logistic regression revealed that individuals with genotype TT at variant rs346473 displayed remarkable correlations with disease progression of HBV infection both in the discovery phase (OR,2.693; 95％ CI,1.928-3.760; P=6.2× 10-9;additive model) and the replication phase (OR,1.490; 95％ CI,1.104-2.012; P=9.0× 10-3; additive model).These two SNPs were in strong linkage disequilibrium with D'=0.99 and r2=0.951,and haplotype TT disclosed an increased susceptibility to HBV progression (OR,1.980; 95％ CI,1.538-2.545;P=8.1× 10-8).These findings suggest that polymorphism rs346473 in the ARHGAP24 gene might be a part of the genetic variants underlying the susceptibility of HBV carriers to disease progression.
