Expressions and significance of STAT3 and p38 in the carcinogenesis of sporadic colorectal tubular adenoma.
- Author:
Hui-min LIU
1
;
Wen-xin WU
;
Xiang-hong ZHANG
;
Gui-hua LÜ
;
Jie-ying ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; metabolism; pathology; Adenoma; metabolism; pathology; Cell Transformation, Neoplastic; metabolism; Colorectal Neoplasms; metabolism; pathology; Gene Expression Regulation, Neoplastic; Humans; Intestinal Mucosa; metabolism; Precancerous Conditions; metabolism; pathology; RNA, Messenger; metabolism; STAT3 Transcription Factor; genetics; metabolism; p38 Mitogen-Activated Protein Kinases; genetics; metabolism
- From: Chinese Journal of Oncology 2007;29(7):514-517
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the possible role of STAT3 and p38 in the carcinogenesis of sporadic colorectal tubular adenoma.
METHODSThe expression of STAT3 and p38 at protein level was studied in 107 sporadic colorectal tubular adenomas with different dysplasia (SCTA-D) or with cancerous changes (SCTA-Ca) by immunohistochemical staining method, meanwhile the expression of STAT3 at mRNA level was detected by in situ hybridization.
RESULTSImmunohistochemical staining results showed that the positive expression rate of STAT3 and p38 was 12.0%, 59.0%, 91.7% and 8.0%, 47.0%, 91.7% in normal colorectal mucosa (NCM), SCTA-D and SCTA-Ca, respectively, with a statistically significant difference of STAT3 and p38 expression among the SCTA-D, SCTA-Ca and NCM (P < 0.05). The expression of STAT3 and p38 was positively correlated with the degree of dysplasia from mild to severe SCTA-D (P < 0.05). In situ hybridization results showed that the positive expression rate of STAT3 at mRNA level in NCM, SCTA-D and SCTA-Ca was 8.00%, 51.8% and 100.0%, respectively, with a statistically significant difference among these either (P < 0.05). The positive expression of STAT3 at mRNA level was not only positively correlated with the degree of dysplasia (P < 0.05), but also with the expression of p38 (P < 0.05).
CONCLUSIONSTAT3 and p38 may be involved in the carcinogenesis of sporadic colorectal tubular adenoma.
