Correlation of tenascin-C degradation fragment with recurrence and/or metastasis in early non-small-cell lung cancer.
- Author:
Ming CAI
1
;
Zong-tao XIE
;
Yuan WENG
;
Qing CHANG
;
Jian-hua CHANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Biomarkers, Tumor; Bone Neoplasms; metabolism; secondary; Brain Neoplasms; metabolism; secondary; Carcinoma, Non-Small-Cell Lung; metabolism; pathology; surgery; Female; Follow-Up Studies; Humans; Lung Neoplasms; metabolism; pathology; surgery; Male; Matrix Metalloproteinase 2; metabolism; Matrix Metalloproteinase 9; metabolism; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Pneumonectomy; Tenascin; metabolism
- From: Chinese Journal of Oncology 2007;29(7):518-521
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the correlation of tenascin-c (TN-C) degradation with relapse and/or metastasis in stage-I non-small cell lung cancer (NSCLC) in order to search for a potential biomarker for predicting recurrence, and also to investigate the molecular mechanism of TN-C degradation. Methods The fragment of TN-C in 63 surgically treated stage-I NSCLC was detected by Western blotting, and the activity of matrix metalloproteinases (MMPs) was also examined by gelatin zymography.
RESULTSTN-C degradation fragment was positively detected in 12 of 63 patients, and 9 of these 12 patients (75.0%) were found to develope recurrence during follow-up. The recurrence-free survival at 4 years was 28.1% in patients with positive TN-C degradation versus 82.1% in those without (P < 0.001), and which was 76.6% at 10 years in the patients without TN-C degradation. The activity of MMP-2 in the patients with positive TN-C degradation was also found to be significantly higher than that in the patients without (P < 0.001).
CONCLUSIONTenascin-c degradation fragment may be a reliable biomarker for predicting recurrence and/or metastasis in the early NSCLC, and matrix metalloproteinase-2 may be a responsible proteinase for degradation of tenascin-c.