Surgical treatment for colorectal cancer with simultaneous hepatic metastasis.
- Author:
Dong-bing ZHAO
1
;
Yi SHAN
;
Cheng-feng WANG
;
Jian-xiong WU
;
Yong-fu SHAO
;
Ping ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; drug therapy; secondary; surgery; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Chemotherapy, Adjuvant; Colectomy; methods; Colonic Neoplasms; drug therapy; pathology; surgery; Female; Follow-Up Studies; Hepatectomy; methods; Humans; Liver Neoplasms; drug therapy; secondary; surgery; Male; Middle Aged; Neoplasm Staging; Proportional Hazards Models; Rectal Neoplasms; drug therapy; pathology; surgery; Rectum; surgery; Survival Rate; Young Adult
- From: Chinese Journal of Oncology 2007;29(7):552-554
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the indication of surgical treatment for primary colorectal carcer with simultaneous hepatic metastasis.
METHODS116 colorectal cancer patients with simultaneous hepatic metastasis underwent surgery from January 1990 to December 2001. The data were analyzed using Statistical Package for the Social Sciences (Release 11.5, SPSS, Inc). The survival was estimated using Kaplan-Meier method, and the survival comparison was carried out using the log-rank test. Multivariate analysis was performed using Cox regression.
RESULTSTotally, 116 patients received surgical resection for primary colorectal tumor, 18 of them underwent liver metastasis resection simultaneously. Postoperative complication developed in 14.7% of these patients with postoperative death in two patients. The overall 5-year survival rate was 14.29%. The 5-year survival rate of those who had liver metastasis resection was 32.12%. Multivariate analysis showed that liver metastasis resection, abdominal carcinomatosis, chemotherapy and intervention treatment were the most important prognostic factors.
CONCLUSIONSurgical resection of primary colorectal cancer with simultaneous resection of liver metastasis or with combined modality therapies such as chemotherapy and intervention treatment is effective to prolong patient's survival for primary colorectal cancer patient with simultaneous hepatic metastasis.
