Studies on self-microemulsifying drug preparations of total flavones of Hippophae rhamnoides.
- Author:
Yan XIE
1
;
Rong RONG
;
Guowen LI
;
Xiurong YUAN
;
Jianying WANG
Author Information
- Publication Type:Journal Article
- MeSH: Calibration; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Compounding; methods; Drug Stability; Drugs, Chinese Herbal; administration & dosage; chemistry; Emulsions; Flavones; chemistry; Hippophae; chemistry; Particle Size; Solubility; Solvents; chemistry; Tablets
- From: China Journal of Chinese Materia Medica 2009;34(1):43-46
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo develop self-microemulsifying preparations of total flavones of Hippophae Rhamnoides L. (TFH) and the determination method of dissolution.
METHODThe equilibrium solubility of TFH in different compositions of oils, emulsifier and assistant emulsifier was investigated. The self-microemulsion formula was optimized by constructing the pseudo-ternary phase diagrams of blank SMEDDS determining the self-microemulsifying efficiency and the stability of the SMEDDS. The 2 hours dissolution curve of TFH self-microemulsifying preparations was established. The optimal self-microemulsion formula was composed of MIGLYOL 812 N, Cremophor EL and 1,2-Propylene glycol.
RESULTThe ratio of them was 0.5:5.7:3.8. The average particle size was 12.1 nm. The dissolution rate at 10 minutes of TFH self-microemulsifying preparation was 131% higher than that of Xinda kang tablets.
CONCLUSIONThe acquired microemulsion with small particle size is stable. The dissolution rate is evidently improved compared with market dosage forms.
