Effects of Sarcandra glabra extract on immune activity in restraint stress mice.
- Author:
Rongrong HE
1
;
Min WANG
;
Yifang LI
;
Yi DAI
;
Yinghui DUAN
;
Xinsheng YAO
;
Hiroshi KURIHARA
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drugs, Chinese Herbal; pharmacology; Killer Cells, Natural; drug effects; immunology; Magnoliopsida; chemistry; Male; Mice; Mice, Inbred C57BL; Natural Killer T-Cells; drug effects; immunology; Restraint, Physical; Stress, Psychological; immunology; T-Lymphocyte Subsets; drug effects; immunology
- From: China Journal of Chinese Materia Medica 2009;34(1):100-103
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the protective effect of Sarcandra glabra extract (SGE) on immune system in restrained mice.
METHODThe male C57BL/6 mice were randomly divided into normal control group, stress control group, 125, 500 mg x kg(-1) SGE group. The spleen lymphocyte suspensions of each group were prepared. The parameters of spleen T cells subsets, NK cell and NKT cell proportion and number was detected by Flow cytometry.
RESULTSGE regulated the balance of T cell subsets, increased the percent of NK cells and NKT cell proportion and number in restrained mice.
CONCLUSIONSGE has immunologic protective effect in restrained mice probably via the amelioration of immune cells proportion and number.
