Studies on extraction of Ligusticum chuanxiong in Hongye Xintong soft capsule by super critical fluid extraction.
- Author:
Yanyu LAN
1
;
Lin ZHENG
;
Yong HUANG
;
Aimin WANG
;
Yongjun LI
;
Xun HE
;
Yonglin WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Capsules; Chromatography, Supercritical Fluid; methods; Coronary Vessels; drug effects; Drugs, Chinese Herbal; chemistry; isolation & purification; pharmacology; Female; Male; Pressure; Rats; Temperature; Time Factors; Water; chemistry
- From: China Journal of Chinese Materia Medica 2009;34(2):161-164
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the rationality of extraction prosess for the Ligusticum chuanxiong in Hongye Xintong Soft Capsule by super critical fluid extraction(SFE).
METHODConditions for the extraction were optimized by orthogonal experimental design as guided by the extraction rate and content of ligustilid in the extract; Combined with the experiment of rats ligated the left coronary artery, the two compounds containing different extracts (steam distillation and SFE) were compared to determine the extraction prosess.
RESULTThe best extraction conditions were established as following: pressure 30 MPa, temperature 50 degrees C, extracting time 4 h, separate pressure 10 MPa. separate temperature 40 degrees C. Compared with steam distillation, the compound containing SFE extract showed stronger protective effects on rats ligated the left coronary artery.
CONCLUSIONSuper critical fluid can extract active ingredients in Ligusticum chuanxiong effectively.
