Study on optimization of formulation and preparation process of sinomenine liposomes.
- Author:
Yan WANG
1
;
Zhenna CONG
;
Qingfei LIU
;
Jiajun LING
;
Liling ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Chemistry, Pharmaceutical; Cholesterol; Dosage Forms; Drug Carriers; Drug Compounding; economics; methods; Drug Delivery Systems; Drug Stability; Liposomes; Morphinans; pharmacokinetics; Particle Size; Phospholipids; Technology, Pharmaceutical
- From: China Journal of Chinese Materia Medica 2009;34(3):275-278
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo optimize the formulation and preparation process of sinomenine liposomes.
METHODMethod of aether injection and mixture uniform design were adopted to determine the formulation of sinomenine liposomes is the proportion of phospholipids, cholesterol and Vitamin E with the index of entrapment efficiency. And the single-factor test was used to study the preparation process of the liposomes, including the volume of buffer solution, the preparation temperature and the ultrasonic time.
RESULTThe optimized formulation was that the ratio of sinomenine : phospholipids : cholesterol : vitamin E mass ratio was 8.92 : 60.35 : 28.81 : 1.91. The volume of buffer solution was 50 mL x g(-1) membrane, the preparation temperature was 50 degrees C, and the ultrasonic time was 20 min.
CONCLUSIONSatisfactory shape and entrapment efficiency of the liposomes can be obtained by the optimized formulation and preparation process.
