Study on Diels-Alder type adducts from stem barks of Morus yunanensis.

Author: Xiqiang CUI ¹ ; Hui CHEN ; Ruoyun CHEN
Author Information

1. Key Laboratory of Bioactive substance and Resources Utilization of Chinese Herbal Medicine, Institute of Materia Medica, Peking Union College and Chinese Academy of Medical Science, Beijing 100050, China.
Publication Type:Journal Article
MeSH: Anti-Inflammatory Agents; pharmacology; Antioxidants; pharmacology; Drugs, Chinese Herbal; Flavonoids; analysis; Morus; chemistry; Plant Bark; chemistry; Plant Extracts; pharmacology; Plant Stems; chemistry; Stilbenes; analysis
From: China Journal of Chinese Materia Medica 2009;34(3):286-290
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo isolate and identify the Diels-Alder type adducts from stem barks of Morus yunanensis.
METHODThe compounds were isolated and purified by silicagel, Sephadex LH-20 and RP-18 colum chromatography. Their chemical structures were elucidated on the basis ofphysicochemical properties and spectral data.
RESULTNine compounds were isolated and identified as: kuwanon G (1), sanggenol M (2), mulberrofuran J (3), guangsangon B (4), resveratrol (5), kuwanon X (6), kuwanon P (7), mulberrofuran O (8), mulberrofuran Q (9).
CONCLUSIONAll the compounds are isolated from the plant for the first time, and compounds 4, 5 have anti-inflammation activities with inhibitory ratios of 57.3%, 50.5% respectively at a concentration of 10 microg mL(-1).