Metabolism and excretion of total flavonoids of Semen Ziziphi Spinosae in rat urine and feces.
- Author:
Lei ZHANG
1
;
Cheng XIANG
;
Bin WANG
;
Yuying ZHAO
;
Qingying ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chromatography, High Pressure Liquid; Feces; chemistry; Flavonoids; analysis; Male; Rats; Rats, Sprague-Dawley; Semen; chemistry; Urine; chemistry
- From: China Journal of Chinese Materia Medica 2009;34(3):340-343
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the metabolism and excretion of total flavonoids of Semen Ziziphi Spinosae in rat urine and feces.
METHODThe urine and feces of rats were collected at different times after orally administration of total flavonoids from Semen Ziziphi Spinosae, disposed by HP-20 macroporous resin, and then detected by both HPLC and LC-MSn methods.
RESULTTwo main proto-drugs, spinosin and 6'"-feruloylspinosin, along with a metabolite, swertish (M1), are detected in both urine and feces of rat.
CONCLUSIONFlavonoids of Semen Ziziphi Spinosae are excreted in urine and feces mainly in form of proto-drug, while little in form of metabolites, such as swertish.
