Effect of Acorus tatarinowii schott on ultrastructure and permeability of blood-brain barrier.
- Author:
Yuan HU
1
;
Mo YUAN
;
Ping LIU
;
Lihua MU
;
Hong WANG
Author Information
- Publication Type:Journal Article
- MeSH: Acorus; chemistry; Animals; Blood-Brain Barrier; drug effects; Brain; cytology; Cells, Cultured; Cerebrovascular Circulation; Drugs, Chinese Herbal; pharmacology; Endothelial Cells; Male; Microscopy, Electron, Transmission; Neurons; diagnostic imaging; drug effects; Permeability; drug effects; Rats; Rats, Sprague-Dawley; Tight Junctions; drug effects; ultrastructure; Ultrasonography
- From: China Journal of Chinese Materia Medica 2009;34(3):349-351
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the influence of Acorus tatarinowii schott on ultrastructure and permeability of BBB.
METHODThe ultrastructure and permeability of BBB on rats with A. tatarinowii by electron microscope were observed. The even's blue (EB) and sodium phenytoin in brain was determined by UV and HPLC-MS.
RESULTAfter give A. tatarinowii, tight junctions of the endothelial cell opened in cotex, and the concentration of EB and sodium phenytoin in brain are significant increased.
CONCLUSIONA. tatarinowii can increase the permeability of BBB, and show its 'Kaiqiao' effect.
