Study on the drug resistance situation among recently infected HIV-I patients in Dehong

VernacularTitle:云南省德宏州HIV-1新近感染者基因型耐药分析
Author: Min-Jie WANG ¹ ; Song DUAN ; Li-Fen XIANG ; Yue-Cheng YANG ; Yuan-Quan TU ; Ji-Bao WANG ; Jun YAO ; Jun QI ; Yan JIANG
Author Information

1. 中国医学科学院肿瘤医院
Keywords: Human immunodeficiency virus; New recent infections; Genotypie resistance
From:Chinese Journal of Epidemiology 2008;29(9):905-908
CountryChina
Language:Chinese
Abstract: Objective To study the HIV-1 drug resistance (DR) situation among newly infected persons in Dehong.Methods 1048 HIV-1 positive blood samples from July to December in 2006 from Dehong prefecture of Yunnan,were collected.HIV drug resistance were tested using TruGene in newly infected people that were distinguished with BED-CEIA,while the subtype were determined with phylogenetic analysis using a set of reference sequences available on the Los Alamos Database.Results Of sixty-four successfully analyzed samples,drug resistance mutations were detected in 4 samples with the resistance rate as 6.25%.Minor mutation in PR region such as M36I/V,L63P and H69K appeared frequently and the rates were 81.25%,70.31%and 65.63%respectively.The predominantly prevalent strains were seen as C/CRF07_BC/08_BC(65.63%,42/64) in this study.Conclusion The prevalence of genotypic drug resistances in HIV-1 recent infections in Dehong prefecture appeared to be at moderate level.Drug-resistance surveillance program among HIV-1 infections should be continued and strengthened.