Study on the relationship between polymorphisms of XPA gene and susceptibility of esophageal cancer
10.3321/j.issn:0254-6450.2008.09.018
- VernacularTitle:XPA基因多态性与食管癌易感性关系的研究
- Author:
Xiang-Xian FENG
1
;
Pei-Fen DUAN
;
Li-Bing WANG
;
Jian-Bin ZHANG
;
Zu-Xun LU
Author Information
1. 华中科技大学同济医学院
- Keywords:
Esophageal cancer;
Genetic polymorphisms
- From:
Chinese Journal of Epidemiology
2008;29(9):930-933
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationships between the polyrnorphisms of xeroderma pigmentosum A(XPA) and the susceptibility of esophageal cancer (EC),as well as its interaction with environmental factors-gene in Changzhi area,Shanxi province. Methods A case-control study was conducted,including 196 cases of EC and 201 controls.XPA 23G polymorphisms were determined with polymerase chain-restriction on fragment length polymorphism (PCR-RFLP).Results The risk of EC was significantly degraded in the individuals who had been carrying the XPA heterozygote (A/G) and mutation genotype (G/G),compared to those with wild genotype (X2=16.21,P＜0.01) and the ORs were 0.58 (0.37-0.91) and 0.32 (0.18-0.56),respectively.There was negative interaction between XPA 23G mutation genotype and the consumption of pickled food (S=0.04,API=-0.77).Conclusion Genetic polymorphism in the XPA 23G might be associated with esophageal cancer in Changzhi area,and there was a negative action between XPA predisposing genotype and the consumption of pielded food.
