Effects of Alternanthera philoxeroides Griseb against respiratory syncytial virus infection in mice.
- Author:
Wen-Ling JIANG
1
;
Zhan-Qiu YANG
;
Wen CHEN
;
Hong XIAO
;
Xian-Ling LUO
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Amaranthaceae; chemistry; Animals; Antiviral Agents; administration & dosage; therapeutic use; Dose-Response Relationship, Drug; Female; Lung; drug effects; pathology; virology; Male; Mice; Mice, Inbred BALB C; Phytotherapy; Plant Preparations; administration & dosage; therapeutic use; Random Allocation; Respiratory Syncytial Virus Infections; drug therapy; Respiratory Syncytial Viruses; drug effects; Treatment Outcome
- From: Journal of Southern Medical University 2007;27(1):62-64
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of an oral preparation of Alternathera philoxeroides Griseb (APG) against respiratory syncytical virus (RSV) in mice.
METHODSAPG preparation was administered orally in RSV-infected mice at different daily doses (2.5, 4.5 and 6.5 g/kg) to observe the therapeutic effect of the preparation.
RESULTSDistinct differences were observed between the death rate of the mice treated with APG at daily dose of 4.5 and 6.5 g/kg and that of the untreated mice with infection. After AGP treatment of the mice at 6.5 g/kg, the detection rate of the virus was 31.3% in the blood and 37.5% in the lung tissue, significantly lower than that in the untreated mice. The virus detection rate was 43.8% in the lung tissues of mice treated with APG at 4.5 g/kg, also significantly lower than that in the untreated control. APG treatment at the 3 doses resulted in different lung indices from that of the control.
CONCLUSIONAPG may be effective for treatment of RSV infection.
