MMP-2/TIMP-2 expression in the trophoblasts of patients with gestational trophoblastic disease.
- Author:
Feng DING
1
;
Qiu-Shi ZHANG
;
Fu-Qi XING
Author Information
- Publication Type:Journal Article
- MeSH: Choriocarcinoma; genetics; metabolism; Female; Gestational Trophoblastic Disease; genetics; metabolism; Humans; Hydatidiform Mole; genetics; metabolism; Hydatidiform Mole, Invasive; genetics; metabolism; Immunohistochemistry; In Situ Hybridization; Matrix Metalloproteinase 2; biosynthesis; genetics; Pregnancy; Tissue Inhibitor of Metalloproteinase-2; biosynthesis; genetics; Trophoblasts; metabolism; Uterine Neoplasms; genetics; metabolism
- From: Journal of Southern Medical University 2007;27(2):150-152
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the role of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of MMP-2 (TIMP-2) in the pathogenesis, development and prognosis of gestational trophoblastic disease (GTD).
METHODSIn situ hybridization and immunohistochemistry were utilized for MMP-2/TIMP-2 mRNA and protein detection in normal chorion of women with early gestation, hydatidiform mole, invasive mole, or choricarcinoma.
RESULTSThe results revealed that specific staining for mRNA and protein of MMP-2 and the expression of TIMP-2 was reduced in normal chorion of early gestation. In GTD ranging from hydatidiform mole, invasive mole to choricarcinoma, MMP-2 expression tended to increase while TIMP-2 expression underwent an invert change. The positivity rate of MMP-2 and TIMP-2 in gestational trophoblastic tumor group was higher than that of the normal chorion of early gestation group and hydatiform mole group (P<0.05 and P<0.001, respectively).
CONCLUSIONA disrupted balance between the activation and inhibition of MMP-2 plays a critical role in the pathogenesis, progression and metastasis of GTD.
