Therapeutic effect of Hongbeiyegen on alcohol-induced rat hepatic fibrosis.
- Author:
Xiao-Yan LÜ
1
;
Qiang LIU
;
Yu-Yao CHEN
;
Yu-Hong SONG
;
Zhi-Ping LÜ
Author Information
- Publication Type:Journal Article
- MeSH: Alanine Transaminase; blood; Animals; Aspartate Aminotransferases; blood; Collagen Type III; blood; Collagen Type IV; blood; Drugs, Chinese Herbal; therapeutic use; Ethanol; Euphorbiaceae; chemistry; Female; Hyaluronic Acid; blood; Laminin; blood; Liver Cirrhosis, Experimental; blood; chemically induced; drug therapy; Male; Phytotherapy; Plant Roots; chemistry; Random Allocation; Rats; Rats, Sprague-Dawley; Tissue Inhibitor of Metalloproteinase-1; blood; Transforming Growth Factor beta1; blood
- From: Journal of Southern Medical University 2007;27(2):153-155
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the therapeutic effect of Hongbeiyegen [the root of Alchornea trewioides(Benth.) Muell.-Arg.] on alcohol-induced liver fibrosis (AF) in rats and explore its mechanism.
METHODSIn rats with AF, the serum levels of transforming growth factor beta1 (TGFbeta1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) were detected along with examination of the changes in serum hyaluronic acid (HA), laminin (LN), procolagen type III (PC III), collagen type IV (C IV), glutamic-pyruvic transaminase (ALT) and glutamic-oxalacetic transaminase (AST) levels.
RESULTSCompared with the control group, Hongbeiyegen could significantly reduce the levels of TGFbeta1, TIMP-1, HA, LN, PC III, CIV, ALT and AST in rats with AF.
CONCLUSIONHongbeiyegen can relieve and ameliorate liver fibrosis possibly by inhibiting the expression of TGFbeta1 and TIMP-1.
