Effects of Chinese Bushen Zhuanggu medicine on bone loss in female rats after simulated weightlessness.
- Author:
Ping SUN
1
;
Zhen HUANG
;
De-Hong CAI
;
Lei HE
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Density; drug effects; Drugs, Chinese Herbal; pharmacology; Female; Osteoporosis; etiology; metabolism; prevention & control; Random Allocation; Rats; Rats, Sprague-Dawley; Weightlessness Simulation; adverse effects
- From: Journal of Southern Medical University 2007;27(2):212-214
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of Bushen Zhuanggu, the traditional Chinese medicine for reinforcing kidney and strengthening bone, on bone loss in female rats after simulated weightlessness.
METHODThirty-six female SD rats were randomly divided into 3 groups, namely normal control group (group A) and two groups of weightlessness simulated by tail suspension (groups B and C). Group C were treated with the Chinese medicine, while groups A and B were given the same dose of normal saline. The experiment lasted 28 days, and all rats were allowed to drink water freely.
RESULTSIn the rats of group B, serum bone Gla protein (BGP), alkaline phosphatase (ALP), estradiol (E(2)) and P content and femur bone mineral content (BMD) were significantly lower than those in group A (P<0.01, P<0.05), whereas serum calcium concentration was markedly higher than that in group A (P<0.01). In rats of group C, serum BGP, ALP, E2 and P content and femur BMD were significantly higher than those in group B (P<0.01, P<0.05), but serum calcium concentration was markedly lower (P<0.01).
CONCLUSIONThis Chinese prescription can stimulate bone formation and reduce bone loss in female rats subjected to simulated weightlessness.
