Lysophosphatidic acid promotes transplanted tumor growth of human epithelium ovarian cancer in nude mice.
- Author:
Hui WANG
1
;
Xiao-Hua WU
;
Li SHI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Female; Lysophospholipids; toxicity; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Ovarian Neoplasms; pathology; Peritoneal Neoplasms; chemically induced; secondary; Random Allocation; Transplantation, Heterologous; Tumor Burden; drug effects
- From: Journal of Southern Medical University 2007;27(2):228-231
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate effect of lysophosphatidic acid (LPA) on growth and metastasis of intraperitonally transplanted tumor in nude mice.
METHODSSixteen nude mice randomly divided into control group and LPA treatment group, in which 6x10(6) untreated and LPA-treated human ovarian cancer cells skov3 were respectively transplanted intraperitoneally. After death of the nude mice without interventions, the weight of the transplanted tumors and number of metastatic tumors were recorded.
RESULTSThe rate of tumor formation was 100%in both groups, but the treatment group showed more rapid tumor growth, greater tumor weight and more numerous metastatic tumors than the control group (P<0.01).
CONCLUSIONLPA simulates the growth and promotes invasiveness of transplanted ovarian cancer cells in the peritoneal cavity of nude mie.
